top2 proteins Search Results


top2 isoforms  (Inspiralis Ltd)
90
Inspiralis Ltd top2 isoforms
<t>TOP2</t> assays. TOP2 activity was analyzed by decatenation assay using purified TOP2 <t>isoforms</t> and catenated DNA. Upper panels show quantification of visualized gels of the inhibition by dexrazoxane (A) and XK469 (B). Lower panels show representative gels of the inhibition of TOP2A (C) and TOP2B (D). TARDIS assay of TOP2-DNA covalent complexes in neonatal cardiomyocytes (E) and wild-type HL-60 cells (F) were incubated with increasing concentrations of either dexrazoxane or XK469 for 2 h. About 100 µM ETO was used as the positive control. Data are expressed as median with an interquartile range of intensities of the individual images. Statistical analyses: n = 4, 1-way ANOVA, Holm-Sidak’s post hoc test, p ≤ .05, “e”—compared with a positive control (100 µM ETO).
Top2 Isoforms, supplied by Inspiralis Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/top2 isoforms/product/Inspiralis Ltd
Average 90 stars, based on 1 article reviews
top2 isoforms - by Bioz Stars, 2026-04
90/100 stars
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top2 inhibition with etoposide treatment  (Human Protein Atlas)
90
Human Protein Atlas top2 inhibition with etoposide treatment
<t>TOP2</t> assays. TOP2 activity was analyzed by decatenation assay using purified TOP2 <t>isoforms</t> and catenated DNA. Upper panels show quantification of visualized gels of the inhibition by dexrazoxane (A) and XK469 (B). Lower panels show representative gels of the inhibition of TOP2A (C) and TOP2B (D). TARDIS assay of TOP2-DNA covalent complexes in neonatal cardiomyocytes (E) and wild-type HL-60 cells (F) were incubated with increasing concentrations of either dexrazoxane or XK469 for 2 h. About 100 µM ETO was used as the positive control. Data are expressed as median with an interquartile range of intensities of the individual images. Statistical analyses: n = 4, 1-way ANOVA, Holm-Sidak’s post hoc test, p ≤ .05, “e”—compared with a positive control (100 µM ETO).
Top2 Inhibition With Etoposide Treatment, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/top2 inhibition with etoposide treatment/product/Human Protein Atlas
Average 90 stars, based on 1 article reviews
top2 inhibition with etoposide treatment - by Bioz Stars, 2026-04
90/100 stars
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human top2a top2 protein  (ACROBiosystems)
N/A
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pierce top 2 abundant protein depletion spin columns  (Thermo Fisher)
N/A
Thermo Scientific Pierce Abundant Protein Depletion Spin Columns are optimized to decrease the abundant albumin and antibody components of human plasma samples in preparation for mass spectrometry or 1D and 2D gel electrophoresis Features of
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Image Search Results


TOP2 assays. TOP2 activity was analyzed by decatenation assay using purified TOP2 isoforms and catenated DNA. Upper panels show quantification of visualized gels of the inhibition by dexrazoxane (A) and XK469 (B). Lower panels show representative gels of the inhibition of TOP2A (C) and TOP2B (D). TARDIS assay of TOP2-DNA covalent complexes in neonatal cardiomyocytes (E) and wild-type HL-60 cells (F) were incubated with increasing concentrations of either dexrazoxane or XK469 for 2 h. About 100 µM ETO was used as the positive control. Data are expressed as median with an interquartile range of intensities of the individual images. Statistical analyses: n = 4, 1-way ANOVA, Holm-Sidak’s post hoc test, p ≤ .05, “e”—compared with a positive control (100 µM ETO).

Journal: Toxicological Sciences

Article Title: Exploring the effects of topoisomerase II inhibitor XK469 on anthracycline cardiotoxicity and DNA damage

doi: 10.1093/toxsci/kfae008

Figure Lengend Snippet: TOP2 assays. TOP2 activity was analyzed by decatenation assay using purified TOP2 isoforms and catenated DNA. Upper panels show quantification of visualized gels of the inhibition by dexrazoxane (A) and XK469 (B). Lower panels show representative gels of the inhibition of TOP2A (C) and TOP2B (D). TARDIS assay of TOP2-DNA covalent complexes in neonatal cardiomyocytes (E) and wild-type HL-60 cells (F) were incubated with increasing concentrations of either dexrazoxane or XK469 for 2 h. About 100 µM ETO was used as the positive control. Data are expressed as median with an interquartile range of intensities of the individual images. Statistical analyses: n = 4, 1-way ANOVA, Holm-Sidak’s post hoc test, p ≤ .05, “e”—compared with a positive control (100 µM ETO).

Article Snippet: We assessed TOP2 activity using both TOP2 isoforms (purchased from Inspiralis, Inc.) using catenated DNA as a substrate.

Techniques: Activity Assay, Purification, Inhibition, Incubation, Positive Control

TOP2B proteasomal degradation in rat neonatal cardiomyocytes . Cells were treated with increasing concentrations of dexrazoxane (DEX) (A) or XK469 (B) for 24 h. Then, TOP2 content in cells was evaluated by immunodetection. Statistical analyses: n = 3–4, mean ± SD, 1-way ANOVA, Holm-Sidak’s post hoc test, p ≤ .05, “c”—compared with drug-free control.

Journal: Toxicological Sciences

Article Title: Exploring the effects of topoisomerase II inhibitor XK469 on anthracycline cardiotoxicity and DNA damage

doi: 10.1093/toxsci/kfae008

Figure Lengend Snippet: TOP2B proteasomal degradation in rat neonatal cardiomyocytes . Cells were treated with increasing concentrations of dexrazoxane (DEX) (A) or XK469 (B) for 24 h. Then, TOP2 content in cells was evaluated by immunodetection. Statistical analyses: n = 3–4, mean ± SD, 1-way ANOVA, Holm-Sidak’s post hoc test, p ≤ .05, “c”—compared with drug-free control.

Article Snippet: We assessed TOP2 activity using both TOP2 isoforms (purchased from Inspiralis, Inc.) using catenated DNA as a substrate.

Techniques: Immunodetection, Control